Peer reviewed journal publications:

79) D. Keskin, G. Zu, A.M. Forson, L. Tromp, J. Sjollema*, P. van Rijn*, "Nanogels: a Novel Approach in Antimicrobial Delivery Systems and Antimicrobial Coatings" Bioactive Materials, 2021, accepted.

78) L. Yang, S. Pijuan-Galito, H. Suk Rho, A. S. Vasilevich, A. Dede Eren, L. Ge, P. Habibović, M. R. Alexander, J. de Boer, A. Carlier, P. van Rijn*, Q. Zhou*, "High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology" Chem. Rev.2021,

77) L. Ribovski, E. de Jong, O. Mergel, G. Zu, D. Keskin, P. van Rijn, I.S. Zuhorn*, "Low nanogel stiffness favors nanogel transcytosis across an in vitro blood–brain barrier", Nanomedicine: Nanotechnology, Biology and Medicine, 2021, 102377

76) G. F. Vasse, P. Buzón, B.N. Melgert*, W.H. Roos*, P. van, Rijn*, “Single Cell Reactomics: Real‐Time Single‐Cell Activation Kinetics of Optically Trapped Macrophages”, Small Methods 2021, 2000849.

75) G.F. Vasse, M. Nizamoglu, I.H. Heijink, M. Schlepütz, P. van Rijn, M.J. Thomas, J.K. Burgess*, B.N. Melgert*, “Macrophage‐stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives”, The Journal of Pathology, 2021,

74) D Keskin, L Tromp, O Mergel, G Zu, E Warszawik, HC van der Mei, P. van Rijn*, “Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels”, ACS Applied Materials & Interfaces, 2020, 12 (52) 57721.

73) G Zu, M Steinmüller, D Keskin, HC van der Mei, O Mergel*, P van Rijn*, “Antimicrobial nanogels with nanoinjection capabilities for delivery of the hydrophobic antibacterial agent triclosan”, ACS applied polymer materials, 2020 2 (12), 5779-5789

72) A.M. Almonacid Suarez , M. G. L. Brinker, L. A. Brouwer, I. van der Ham, M. C. Harmsen*, P. van Rijn* "Topography-Mediated Myotube and Endothelial Alignment, Differentiation, and Extracellular Matrix Organization for Skeletal Muscle Engineering" Polymers2020, 12, 1948.

71) L. Yang, L. Ge, Q. Zhou, T. Mokabber, Y. Pei, R. Bron, P. van Rijn* "Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells" Adv. Mater. Interfaces 2020, 7, 2000385.

70) G. Zu, O. Mergel, L. Ribovski, R. Bron, I. Zuhorn*, P. van Rijn* "Nanogels with selective intracellular reactivity for intracellular tracking and delivery" Chem. Eur. J. 2020 26(66), 15084.

69) L. Ribovski, Q. Zhou, J. Chen, B. L. Feringa, P. van Rijn*, I. S. Zuhorn* “Light-induced molecular rotation triggers on-demand release from liposomesChem. Commun. 2020, 56, 8774-8777.

68) A. M. Almonacid Suarez, I. van der Ham, M. G.L. Brinker, P. van Rijn*, M. C. Harmsen* “Topography-driven alterations in endothelial cell phenotype and contact guidanceHeliyon 2020, 6, e04329.

67) L. Yang*, L. Ge. P. van Rijn*, “Synergistic Effect of Cell-Derived Extracellular Matrices and Topography on Osteogenesis of Mesenchymal Stem Cells”, ACS Appl. Mater. Interfaces2020, 12, 23, 25591–25603.

66) L. Yang, L. Ge, Q. Zhou, K. Jurczak, P. van Rijn, "Decoupling amplitude and wavelength of anisotropic topography and the influence on osteogenic differentiation of mesenchymal stem cells using a high-throughput screening approach", ACS Appl. Bio Mater.2020,

65) L. Yang, K. M. Jurczak, L. Ge, P. van Rijn, "High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells", Adv. Healthcare Mater.2020, 2000117.

64) L. Han, Q. Yin, L. Yang, P. van Rijn, Y. Yang, Y. Liu, M. Li, M. Yan, Q. Zhou, T. Yu, Z. Lian, "Biointerface topography regulates phenotypic switching and cell apoptosis in vascular smooth muscle cells", Biochemical and Biophysical Research Communications, 2020, 526, 3, 841-847.

63) L. Ge, L. Yang, R. Bron, J. K. Burgess, P. van Rijn, "Topography-Mediated Fibroblast Cell Migration Is Influenced by Direction, Wavelength, and Amplitude", ACS Appl. Bio Mater. 2020, 3, 4, 2104–2116.

62) Y. Liu, W. Deng, L. Yang, X. Fu, Z. Wang, P. van Rijn, Q. Zhou, T. Yu, "Biointerface topography mediates the interplay between endothelial cells and monocytes", RSC Adv., 2020, 10, 13848-13854.

61) L. Yang, Q. Gao, L. Ge, Q. Zhou, E. M Warszawik, R. Bron, K. W. Chiu Lai, P. van Rijn, "Topography induced stiffness alteration of stem cells influences osteogenic differentiation", Biomater. Sci., 2020, 8, 2638-2652.

60) Q. Zhou, J. Chen, Y. Luan, P.A. Vainikka, S. Thallmair, S. J. Marrink, B.L. Feringa*, P. van Rijn*, "Unidirectional rotating molecular motors dynamicallyinteract with adsorbed proteins to direct the fateof mesenchymal stem cells", Sci. Adv. 2020, 6 : eaay2756.

Press: & & & &

59) T. Mokabber, H.T. Cao, N. Norouzi, P. van Rijn*, Y. Pei, "Antimicrobial electrodeposited silver-containing calcium phosphate coatings", ACS Appl. Mater. Interfaces 2020, 12, 5, 5531-5541.

58) T.A.B. van der Boon, L. Yang, L. Li, D.E. Córdova Galván, Q. Zhou, J. de Boer, P. van Rijn*, "Well Plate Integrated Topography Gradient Screening Technology for Studying Cell‐Surface Topography Interactions", Advanced Biosystems, 2020, 1900218.

57) A.M. Almonacid Suarez, Q. Zhou, P. van Rijn*, M.C. Harmsen*, "Directional topography gradients drive optimum alignment and differentiation of human myoblasts", J Tissue Eng Regen Med. 2019, 13, 2234– 2245.

56) D. B. Gehlen, L.C. De Lencastre Novaes, W. Long, A. J. Ruff, F. Jakob, T. Haraszti, Y. Chandorkar, L. Yang, P. van Rijn, U. Schwaneberg, L. De Laporte*, "Rapid and Robust Coating Method to Render Polydimethylsiloxane Surfaces Cell-Adhesive", ACS Appl. Mater. Interfaces 2019, 11, 44, 41091-41099.

55) G. Romero Liguori, Q. Zhou, T. Tavares Aquinas Liguori, G. Garcia Barros, P. Till Kühn, L. Felipe Pinho Moreira, P. van Rijn*, M. C. Harmsen*, “Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis”, Stem Cells International, 2019, Article ID 5387850.

54) S. Brosel-Oliu, O. Mergel, N. Uria, N. Abramova, P. van Rijn and  A. Bratov*, “3D impedimetric sensors as a tool for monitoring bacterial response to antibiotics”, Lab on a Chip, 2019, doi:10.1039/C8LC01220B.

53) T. Mokabber, Q. Zhou, A.I. Vakis, P. van Rijn*, Y.T. Pei, “Mechanical and biological properties of electrodeposited calcium phosphate coatings”, Mater. Sci. Engin. C, 2019, 100, 475-484,

52) G. Zu, Y. Cao, J. Dong, Q. Zhou, P. van Rijn, M. Liu, and R. Pei*, “Development of an Aptamer-Conjugated Polyrotaxane-Based Biodegradable Magnetic Resonance Contrast Agent for Tumor Targeted Imaging”, ACS Appl. Bio Mater., 2019, DOI: 10.1021/acsabm.8b00639.

51) D. keskin, O. Mergel*, H. C Van der Mei, H. J Busscher, P. van Rijn*, ”Inhibiting Bacterial Adhesion by Mechanically Modulated Microgel Coatings”, Biomacromolecules, 2019, DOI:10.1021/acs.biomac.8b01378.

50) O. Mergel, S. Schneider, R. Tiwari, P. T. Kuhn, D. Keskin, M. C. A. Stuart, S. Sch¨ottner, M. de Kanter, M. Noyong, T. Caumanns, J. Mayer, C. Janzen, U. Simon, M. Gallei, D. Woll, P. van Rijn and F. A. Plamper*, “Cargo shuttling by electrochemical switching of core–shell microgels obtained by a facile one-shot polymerization”, Chem. Sci., 2019, DOI: 10.1039/c8sc04369h

49) V. Vignali, B. S. Miranda, I. Lodoso-Torrecilla, C. A. J. van Nisselroy, B. Hoogenberg, S. Dantuma, F. Hollmann, J. W. de Vries, E. M. Warszawik, R. Fischer, U. Commandeur and P. van Rijn*, “Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13”, Chem. Commun., 2019, 55, 51.

48) Q. Zhou, L. Ge, C. Guimarães, P.T. Kühn, L. Yang, P. van Rijn*, “Development of a Novel Orthogonal Double Gradient for High-Throughput Screening of Mesenchymal Stem Cells–Materials Interaction”, Adv. Mater. Interfaces, 2018, 1800504.

47) D. Keskin, T. Mokabbar, Y. Pei, P. van Rijn*, “The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties”, Polymers, 2018, 10, 534.

46) Q. Zhou, Z. Zhao, Z. Zhou, G. Zhang, R. Chiechi*, ,P. van Rijn*, “Directing Mesenchymal Stem Cells with Gold Nanowire Arrays”, Adv. Mater. Interfaces, 2018, 1800334.

45) S. Jiangnan,… P. van Rijn (7th),…, X-Y. Yang*, “bFGF and Poly-RGD Cooperatively Establish Biointerface for Stem Cell Adhesion, Proliferation and Differentiation”, Adv. Mater. Interfaces2018, 1700702.

44) G. Vasse, P. Kühn, Q. Zhou, S. Bhusari, C. Reker-Smit, B. Melgert*, P. van Rijn*, “Collagen morphology influences macrophage shape and marker expression in vitro”, J. Immun. Regenerative Med. 2018, 1, 13-20.

43) T. Mokabber, P. van Rijn, A. Vakis, Y. Pei*, “Crystal growth mechanism of calcium phosphate coatings on titanium by electrochemical deposition”, Surf. Coat. Technol. 2018, 334, 526.

42) Q. Zhou, H. Zhang, Y. Zhou, Z. Yu, H. Yuan, B. Feng, P. van Rijn, Y. Zhang*, “Alkali-Mediated Miscibility of Gelatin/Polycaprolactone for Electrospinning Homogeneous Composite Nanofibers for Tissue Scaffolding”, Macromol. Biosci.2017, 1700268.

41) Q. Zhou, O. Castañeda Ocampo, C. Guimarães, P.T. Kühn, T.G. van Kooten, P. van Rijn*, “Screening platform for cell contact guidance based on inorganic biomaterial micro/nanotopographical gradients”, ACS Appl. Mater. Interfaces, 2017, 9 (37), 31433.

40) G. Abagnale, A. Sechi, M. Steger, Q. Zhou, C.-C. Kuo, G. Aydin, C. Schalla, G. Müller-Newen, M. Zenke, I.G. Costa, P. van Rijn, A. Gillner, W. Wagner*, “Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies”, Stem Cell Report, 2017, 9, 1-13.

39) P.T. Kühn, R.T. Rozenbaum, E. Perrels, P.K. Sharma, P. van Rijn*, “Anti-Microbial Biopolymer Hydrogel Scaffolds for Stem Cell Encapsulation”, Polymers, 2017, 9, 149.

38) P.T. Kühn, T.L. Meijer, I. Schiavon, M. van Poll, J. van Aken, S. Groen, R. Kuijer, T.G. van Kooten, P. van Rijn*, “Non-covalently stabilized alginate hydrogels as functional cell scaffold material”, Macromol. Biosci.2016, 16, 11, 1696.

37) P. Wünnemann, M. Noyong, K. Kreuels, , R. Brüx, , P. Gordiichuk, P., van Rijn, F.A. Plamper, U. Simon, A. Böker*, “microstructured hydrogel templates for the formation of conductive gold nanowite arrays”, Macromol. Rapid Commun.2016, 37, 1446.

36) Q. Zhou, P. Wünnemann, P. T. Kühn, J. de Vries, M. Helmin, A. Böker, T. G. van Kooten, P. van Rijn*, “ Mechanical properties of aligned nanotopologies for directing cellular behaviorAdv. Mater. Interfaces, 2016, 1600275.

35) P. van Rijn*, R. Schirhagl*, “Viruses, artificial viruses and virus-based structures for biomedical applications”, Adv. Healthcare Mater., 2016, 5, 12, 1386.

34) P. T. Kuhn, Q. Zhou, T. van der Boon, A. M. Schaap-Oziemlak, T. G. van Kooten, P. van Rijn*, “Double linear gradient biointerfaces for determining two-parameter dependent stem cell behaviorChemNanoMat, 2016, 2, 407.

33) Q. Zhou, P. T. Kühn, T. Huisman, E. Nieboer, C. van Zwol, T. G. van Kooten, P. van Rijn*, “Directional nanotopographic gradients” a high-throughput screening platform for cell contact guidanceSci. Rep.2015, 5, 16240.

32) P.T. Kuhn, B.S. de Miranda, P. van Rijn*, “Directed autonomic flow: functional motility fluidicsAdv. Mater., 2015, 27, 7401.

31) G. Jutz#, P. van Rijn#, B.S. de Miranda, A. Böker*, “Ferritin: A versatile building block for bionanotechnology” Chem. Rev. 2015, 115 (4), 1653. (highly cited indicated by Web of Science: cited 107)

30) P. van Rijn*, L.S. van Bezouwen, R. Fischer, E.J. Boekema, A. Böker, U. Commandeur*, “Virus-SiO2 and virus-SiO2-Au hybrid particles with tunable morphologyPart. Part. Syst. Charact., 2015, 32, 43.

29) A.M. Schaap, P.T. Kuhn, T.G. van Kooten, P. van Rijn*, “Biomaterial-stem cell interactions and its impact on stem cell behaviour”, RSC Adv., 2014, 4, 53307.

28) P. van Rijn, M. Tutus, C. Kathrein, N.C. Mougin, H. Park, C. Hein, M.P. Schürings, A. Böker, “Ultra-Thin Self-Assembled Protein-Polymer Membranes: A New Pore Forming Strategy”, Adv. Funct. Mater., 2014, 24, 6762.

27) D. Janeliunas, P. van Rijn, J. Boekhoven, C. B. Minkenberg, J. H. van Esch, R. Eelkema, “Aggregation-Driven Reversible Formation of Conjugated Polymers in Water” Angew. Chem. Int. Ed.2013, 52, 1998.

26) S. S. Hosseiny, P. van Rijn*,"Surface Initiated Polymerizations via e-ATRP in Pure Water" Polymers, 2013, 5(4), 1229.

25) H. Wang, T. M. Garakani, T. Krappitz, P. van Rijn*, A. Böker*,"Morphology control and surface functionalization of Protein-SiO2 hybrid capsules" J. Mater. Chem. B, 2013, 1, 6472.

24) G. Agrawal, Marco P. Schuerings, P. van Rijn*, A. Pich*,“Formation of catalytically active gold-polymer microgel hybrids via a controlled in situ reductive process” J. Mater. Chem. A, 2013, 1, 13244.

23) P. van Rijn*, M. Tutus, C. Kathrein, L. Zhu, M. Wessling, U. Schwaneberg, A. Böker, “Challenges and Advances in the Field of Self-Assembled Membranes” Chem. Soc. Rev., 2013, 42, 6578.

22) P. van Rijn*,“Polymer directed Protein Assembly” Polymers, 2013, 5, 576.

21) K. Ö. Nazli, C. W. Pester, A. Konradi, A. Böker, P. van Rijn*,“Cross-linking Density and Temperature Effects on the Self-Assembly of SiO2-PNIPAAm Core-Shell Particles at Interfaces” Chem. Eur. J., 2013, 19, 5586.

20) P. van Rijn, H. Park, N. C. Mougin, A. Böker, “Interfacial properties of Ferritin-polymer conjugates for Pickering emulsion stabilizers” Langmuir 2013, 29, 276.

19) P. van Rijn, N. C. Mougin and A. Böker, “Hierarchical Micro-Compartmentalization via Self-Assembly of a Protein-Polymer Conjugate” Polymer, 2012, 53, 6045.

18) T. M. Garakani, H. Wang, T. Krapitz, P. van Rijn*, A. Böker*,“Morphology control of lysozyme-silica hybrid structures via simple preparation variations” Chem. Commun., 2012, 48, 10210.

17) S. Park, P. van Rijn, A. Böker, “Artificial Leaves via Reproduction of Hierarchical Structures by a Fast Molding and Curing Process” Macromol. Rapid Commun., 2012, 33, 1300.

16) C. W. Pester, A. Konradi, B. Varnholt, P. van Rijn* and A. Böker, “Responsive Macroscopic Materials from Self-Assembled Cross-linked SiO2-PNIPAAm Core-shell structures” Adv. Funct. Mater., 2012, 22, 1723.

15) P. van Rijn* and A. Böker*,“Bionanoparticles and hybrid materials: tailored structural properties, self-assembly, materials and developments in the field” J. Mater. Chem., 2011, 21, 16735.

14) A. Schulz, H. Wang, P. van Rijn and A. Böker, “Synthetic inorganic materials by mimicking biomineralization processes using native and non-native protein functions” J. Mater. Chem., 2011, 21, 18903.

13) C. W. Pester, M. Ruppel, H. G. Schoberth, K. Schmidt, C. Liedel, P. van Rijn, K. Schindler, S. Hiltl, T. Czubak, V. S. Urban, A. Böker, “Quasi-Piezoelectric Susceptibility of Nanostructured Block Copolymers” Adv. Mater., 2011, 23, 4047.

12) P. van Rijn, H. Wang and A. Böker, “Ultra-sound assisted formation of biodegradable double emulsion capsules from hen egg white” Soft Matter, 2011, 7 (11), 5274.

11) P. van Rijn, N. C. Mougin, D. Franke, H. Park, A. Böker, “Pickering emulsion templated soft capsules by self-assembling cross-linkable ferritin–polymer conjugates” Chem. Commun., 2011, 47, 8376.

10) N. C. Mougin, P. van Rijn, H. Park, A.H.E. Müller and A. Böker, “Hybrid Capsules via Self-Assembly of Thermo-Responsive and Interfacially Active Bionanoparticle-Polymer Conjugates” Adv. Funct. Mater., 2011, 21, 2470.

9) D. T. Schühle, P. van Rijn, S. Laurent, L. Vander Elst, R. N. Muller, M. C. A. Stuart, J. Schatz, J. A. Peters, “Liposomes with Conjugates of a Calix[4]arene and a Gd-DOTA Derivative on the Outside Surface; an Efficient Potential Contrast Agent for Magnetic Resonance Imaging” Chem. Commun., 2010, 46, 4399.

8) J. Boekhoven, A. M. Brizard, P. van Rijn, M. C. A. Stuart, R. Eelkema, G. J.M. Koper, J. H. van Esch, “Programmed Morphological Transitions of Multi-segment Amphiphile Assemblies by Simple Chaperone Analogs.” Angew. Chem. Int. Ed.2011 , 50 , 12285.

7) C. B. Minkenberg, F. Li, P. van Rijn, L. Florusse, J. Boekhoven, M. C. A. Stuart, G. J. M. Koper, R. Eelkema, and J. H. van Esch, “Responsive Vesicles from Dynamic Covalent Surfactants” Angew. Chem. Int. Ed.2011, 50, 3421.

6) P. van Rijn, D. Janeliunas, A. M. A. Brizard, M. C. A. Stuart, G. J. M. Koper, R. Eelkema and J. H. van Esch, “Self-assembly of conjugated terthiophene surfactants in water” New J. Chem., 2011, 35, 558.

5) P. van Rijn, D. Janeliunas, A. M. A. Brizard, M. C. A. Stuart, R. Eelkema and J. H. van Esch, “Self-assembly of curved amphipathic oligothiophenes for defined aggregate formation” Chem. Eur. J., 2010, 16, 13417.

4) J. Boekhoven, P. van Rijn, A. M. A. Brizard, M. C. A. Stuart and J. H. van Esch, “Synthesis and Self-Assembly of a Novel Multisegment Amphiphile Leading to Microdomain Separation” Chem. Commun., 2010, 46, 3490.

3) P. van Rijn, T. J. Savenije, M. C. A. Stuart and J. H. van Esch, “Amphiphilic conjugated thiophenes for self- assembling antenna systems in water” Chem. Commun., 2009, 2163.

2) J.J.D. de Jong, P. van Rijn, T. D. Tiemersma-Wegeman, L. N. Lucas, W. R. Browne, R. M. Kellogg, K. Uchida, J. H. van Esch, B. L. Feringa, “Dynamic chirality, chirality transfer and aggregation behaviour of dithienylethene switches” Tetrahedron, 2008, 64, 8324.

1) O. Azzaroni, B., Trappmann, P. van Rijn, F. Zhou, B. Kong, W. T. S. Huck, “Mechanically-induced Generation of Counterions inside Surface Grafted Charged Macromolecular Films: Towards Enhanced Mechanotransduction in Artificial Systems” Angew. Chem. Int. Ed.2006, 45, 7440.


1) “Bio-Synthetic Hybrid Materials and Bionanoparticles” as part of the “RSC Smart Materials Series” Editors: Alexander Böker and Patrick van Rijn. ISBN: 978-1-84973-822-4.

Book chapters:

1) Chapter 1: “Synthetic Modifications of Proteins”, U. Glebe, B. Santos de Miranda, P. van Rijn*, A. Boker*

2) Chapter 2: “Inorganic–Protein Hybrid Bionanostructures”, P. van Rijn*

3) Chapter 5: “Intra- and Intermolecular Bionanoparticle Self-Assembly as Functional Systems”, B. Santos de Miranda, J. Sjollema, P. van Rijn*

4) Chapter 6: “Self-Assembling Properties of Bionanoparticles at Liquid/Liquid and Liquid/Air Interfaces”, M. J. Richter, P. van Rijn*, A. Boker*

5) “Biomaterials Surface Science; Structured and Functional Surfaces via the assembly of bionanoparticles at interfaces.” Editors: J. Carlos Rodriguez-Cabello, Joao Mano, Andreas Taubert; Authors: S. Hiltl, A. Schulz, P. van Rijn, Alexander Böker. Wiley, 2013, ISBN: 978-3-527-33031-7.

6) “Supramolecular Chemistry: From Molecules to Nanomaterials. Volume 6: Supramolecular Nanotechnology; Section 9: Soft Matter; Self-Assembly of Surfactants in Liquids: Self-Assembly of Facial Amphiphiles in Water.” Editors: Philip A. Gale and Jonathan W. Steed; Authors: J. Boekhoven, P. van Rijn, J. H. van Esch. Wiley. 2012, ISBN: 978-0-470-74640-0.


1) “Novel biomaterials substrates, cell culture systems comprising the same and uses thereof in cell screening applications” Patrick van Rijn, Martin C. Harmsen, Qihui Zhou, Philipp T. Kühn, Gabriel Liguori; Feb. 2017, P113777EP00 No. 17157897.4

2) “Amphipathic curved oligothiophene as a tool for detecting membrane curvatures in biological processes in living cells” Jan H. van Esch, Patrick van Rijn, Marcel A. Raspe, Eric A. J. Reits. ref.: 2009 OCT-09-067- Curvature membrane visualisation / ref: P91359NL00 nr. 2004757.

Refereed conference proceedings:

1) “ORGN 117-Amphiphilic conjugated molecules for functional nano-architectures”
van Rijn P.; Stuart M. C. A.; van Esch J. H. Abstracts of papers of the American Chemical Society, Volume: 234, Meeting Abstract: 117-ORGN, AUG 19, 2007